Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI

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Objective: To report a case of Turner mosaicism with low oocyte maturity during ICSI. Design: Retrospective case report. Setting: Academic tertiary medical center. Patient(s): A 28-year-old patient with 7-year history of primary unexplained infertility. Intervention(s): Four cycles of ICSI. Main Outcome Measure(s): Oocyte quality; fertilization, cleavage, and implantation rates; and live births during ICSI cycles; as well as patient karyotype were obtained. Result(s): Over four cycles of ICSI, 111 oocytes were harvested, a high follicular response, but 68% were immature (germinal vesicles or metaphase I). Additionally, seven embryos were transfered, but none implanted. Owing to this unusual response in a young healthy woman, maternal karyotype was performed, which demonstrated 17% Turner mosaicism. Conclusion(s): This is, to our knowledge, the first reported case of excellent ovarian response but marked oocyte immaturity in a young woman with Turner mosaicism. The implications of sex chromosome aneuploidy on fertility and the significance of low oocyte maturity are discussed. © 2008 American Society for Reproductive Medicine.




Moore, A. K., Lynch, K., Arny, M. J., & Grow, D. R. (2008). Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI. Fertility and Sterility, 90(5), 2012.e13-2012.e15. https://doi.org/10.1016/j.fertnstert.2008.03.063

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