Bacterial inhibitory activity of a new Schiff base derived from thiazole complemented with gravimetrical and theoretical investigations

Abstract

The growth of bacterial resistance has been shown to reduce the effectiveness of current antibacterial drugs, necessitating the development of additional effective antibiotics to treat infections. Various investigations showed an increase in antibacterial effect after testing various natural and synthetic organic compounds. The current investigation applied a methodology appropriate and convenient for studying the antibacterial effects toward selected types of Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Proteus vulgaris). A thiazole Schiff base derivative, namely ethyl 2-(1-phenylethylideneamino)thiazole-4-carbonate (PT4C), was evaluated as an antibacterial agent by the disc diffusion method. The antibacterial findings showed a significant activity of the tested compound against all the selected types of bacteria. In a parallel work, the corrosion inhibition characteristics of PT4C toward mild steel in 1.0 M hydrochloric acid solution was also evaluated by the weight loss technique. Experimental findings show that PT4C exhibits excellent inhibition efficiency. Moreover, quantum chemical computations were conducted. The corrosion inhibition mechanism was suggested based on the weight loss results and DFT calculations.