High level of carbapenem resistance and transmission ability of bla IMP-26 in multidrug-resistant Enterobacter xiangfangensis isolates from China

Abstract

Our research has led to the documentation of a novel IncpKPC-CAV1321 plasmid and the discovery of a novel integron In437, both carrying the bla IMP-26 gene. A comprehensive analysis of the carbapenem resistance levels and enzymatic kinetics exhibited by IMP-26 revealed that IMP-26 could mediate high levels of resistance to common carbapenem and cephalosporin antibiotics. Our findings underscore the critical need for enhanced surveillance and preventive measures to curtail the dissemination of bla IMP-26 .