Autoimunidade tireoidiana em pacientes com hiperprolactinemia: Um estudo observacional

14Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Objective: To establish whether there is a relationship between hyperprolactinemia and primary thyroid disorders, focusing on patients with autoimmune features. Materials and methods: The medical records of 100 patients with hyperprolactinemia (HPRL) were retrospectively examined. Records of thyroid ultrasonography (USG), basal serum levels of thyroid stimulating hormone, circulating free thyroxine, free triiodothyronine, antithyroglobulin (anti-Tg), and antithyroperoxidase (anti-TPO) antibodies were analyzed. In 100 control subjects, matched by age and gender with HPRL patients, thyroid USG, thyroid function tests (TFTs), and autoantibody panel were obtained. Results: The median PRL in patients was 93 ng/mL (range: 37-470). Twenty-five patients (25%) and 22 controls (22%) had positive anti-Tg and/or anti-TPO titers (P = 0.739). The median serum PRL was 98 (37-470) ng/mL in patients with positive thyroid autoantibodies, and 92 (40-470) ng/mL in patients who were negative (P = 0.975). Among the individuals with autoantibody positivity TFTs abnormalities were more frequent in HPRL patients (60%, out of 25 patients, 14 with subclinical hypothyroidism and one with hyperthyroidism) than in controls (9.1%, out of 22 patients, 2 with subclinical hyperthyroidism) (P < 0.001). Twenty-seven patients with HPRL and 31 controls had goiter (27 vs. 31%, P = 0.437). Fortysix patients (46%) and 50 (50%) controls had one or more of the features of thyroid disorder, which were goiter, positive thyroid autoantibody, and thyroid function abnormality (P = 0.888). Conclusion: HPRL may be associated with more severe thyroid dysfunction in patients with thyroid autoimmunity. © ABE&M todos os direitos reservados.

Cite

CITATION STYLE

APA

Onal, E. D., Saglam, F., Sacikara, M., Ersoy, R., & Cakir, B. (2014). Autoimunidade tireoidiana em pacientes com hiperprolactinemia: Um estudo observacional. Arquivos Brasileiros de Endocrinologia e Metabologia, 58(1), 48–52. https://doi.org/10.1590/0004-2730000002846

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free