Abstract
WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2, a major component, and minor components A1, A4, Ax8, Ax9 and Ax13 were active against Gram-positive bacteria, in particular, methicillin-resistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.
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CITATION STYLE
Kato, A., Nakaya, S., Kokubo, N., Aiba, Y., Ohashi, Y., Hirata, H., … Harada, K. I. (1998). A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities. Journal of Antibiotics, 51(10), 929–935. https://doi.org/10.7164/antibiotics.51.929
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