Rodriguez et al. show that GM-CSF and M-CSF give rise to opposing phenotypes in the context of inflammation. Inflammation induced by GM-CSF is mediated by JAK2 and the downstream MAPK signaling pathway. However, PI3K signaling is associated with a negative regulatory loop of this program and the stimulation of autocrine production of M-CSF.
Rodriguez, R. M., Suarez-Alvarez, B., Lavín, J. L., Ascensión, A. M., Gonzalez, M., Lozano, J. J., … Lopez-Larrea, C. (2019). Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes. Cell Reports, 29(4), 860-872.e5. https://doi.org/10.1016/j.celrep.2019.09.035