We found that most peripheral CD4 cells co-express a low density of CD8α antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8(low) cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8(low) cells were resistant to SIV infection after their conversion to CD4- cells.
CITATION STYLE
Murayama, Y., Amano, A., Mukai, R., Shibata, H., Matsunaga, S., Takahashi, H., … Noguchi, A. (1997). CD4 and CD8 expressions in African green monkey helper T lymphocytes: Implication for resistance to SIV infection. International Immunology, 9(6), 843–851. https://doi.org/10.1093/intimm/9.6.843
Mendeley helps you to discover research relevant for your work.