CD4 and CD8 expressions in African green monkey helper T lymphocytes: Implication for resistance to SIV infection

46Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We found that most peripheral CD4 cells co-express a low density of CD8α antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8(low) cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8(low) cells were resistant to SIV infection after their conversion to CD4- cells.

Cite

CITATION STYLE

APA

Murayama, Y., Amano, A., Mukai, R., Shibata, H., Matsunaga, S., Takahashi, H., … Noguchi, A. (1997). CD4 and CD8 expressions in African green monkey helper T lymphocytes: Implication for resistance to SIV infection. International Immunology, 9(6), 843–851. https://doi.org/10.1093/intimm/9.6.843

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free