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Reversible DNA micro-patterning using the fluorous effect

Chemical Communications (2017) 53(21) 3094-3097
DOI: 10.1039/c7cc00288b
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Abstract

We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.

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Flynn, G. E., Withers, J. M., Macias, G., Sperling, J. R., Henry, S. L., Cooper, J. M., … Clark, A. W. (2017). Reversible DNA micro-patterning using the fluorous effect. Chemical Communications, 53(21), 3094–3097. https://doi.org/10.1039/c7cc00288b

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