Leptin-induced weight loss is not solely mediated by anorexia

Abstract

In summary, the important new studies by (Friedman's group (14) show that suppression of the fatty acid-synthesizing enzyme SCD-1 can correct the hypometabolic phenotype of leptin deficiency, showing that leptin not only works via central anorectic effects but also by increasing hepatic fatty acid oxygenation (Fig. 1).