Platelet monoamine oxidase B activity in Parkinsonian patients

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Abstract

Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

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Bonuccelli, U., Piccini, P., Del Dotto, P., Muratorio, A., Pacifici, G. M., & Corsini, G. U. (1990). Platelet monoamine oxidase B activity in Parkinsonian patients. Journal of Neurology, Neurosurgery and Psychiatry, 53(10), 854–855. https://doi.org/10.1136/jnnp.53.10.854

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