Perinatal morbidity and mortality associated with chlamydial infection: A meta-analysis study

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Abstract

Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. Results: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). Conclusion: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings. © 2011 Elsevier Editora Ltda.

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de Attayde Silva, M. J. P. M., Dantas Florêncio, G. L., Erbolato Gabiatti, J. R., do Amaral, R. L., Júnior, J. E., & da Silveira Gonçalves, A. K. (2011). Perinatal morbidity and mortality associated with chlamydial infection: A meta-analysis study. Brazilian Journal of Infectious Diseases, 15(6), 533–539. https://doi.org/10.1016/S1413-8670(11)70247-1

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