Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer.
Valk-Lingbeek, M. E., Bruggeman, S. W. M., & Van Lohuizen, M. (2004, August 20). Stem cells and cancer: The polycomb connection. Cell. https://doi.org/10.1016/j.cell.2004.08.005