Polyelectrolyte complex containing silver nanoparticles with antitumor property on Caco-2 colon cancer cells

24Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

Polyelectrolyte complex (beads) based on N,N,N-trimethyl chitosan/alginate was successful obtained and silver nanoparticles (AgNPs) were loaded within beads. In vitro cytotoxicity assays using beads/silver nanoparticles (beads/AgNPs) provided results, indicating that this material significantly inhibited the growth of colon cancer cells (Caco-2). In vitro release studies showed that the beads stabilized AgNPs and repressed Ag<sup>0</sup> oxidation under gastric conditions (pH 2.0). On the other hand, at physiological condition (pH 7.4) the beads/AgNPs released 3.3μg of Ag<sup>+</sup> per each beads milligram. These studies showed that the concentration of Ag<sup>+</sup> released (3.3μg) was cytotoxic for the Caco-2 cells and was not cytotoxic on healthy VERO cells. This result opens new perspectives for the manufacture of biomaterials based on beads/AgNPs with anti-tumor properties.

Cite

CITATION STYLE

APA

Martins, A. F., Follmann, H. D. M., Monteiro, J. P., Bonafé, E. G., Nocchi, S., Silva, C. T. P., … Muniz, E. C. (2015). Polyelectrolyte complex containing silver nanoparticles with antitumor property on Caco-2 colon cancer cells. International Journal of Biological Macromolecules, 79, 748–755. https://doi.org/10.1016/j.ijbiomac.2015.05.036

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free