All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection

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Abstract

We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.

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Mocanu, E., Shattock, R., Barton, D., Rogers, M., Conroy, R., Sheils, O., … O’Leary, J. (2010). All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection. Fertility and Sterility, 94(6), 2448–2450. https://doi.org/10.1016/j.fertnstert.2010.02.029

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