Dialysate flow rate and delivered kt/v urea for dialyzers with enhanced dialysate flow distribution

Abstract

Background and objectives: Previous in vitro and clinical studies showed that the urea mass transfer-area coefficient (K o) increased with increasing dialysate flow rate. This observation led to increased dialysate flow rates in an attempt to maximize the delivered dose of dialysis (Kt/V urea). Recently, we showed that urea K oA was independent of dialysate flow rate in the range 500 to 800 ml/min for dialyzers incorporating features to enhance dialysate flow distribution, suggesting that increasing the dialysate flow rate with such dialyzers would not significantly increase delivered Kt/V urea. Design, setting, participants, & measurements: We performed a multi-center randomized clinical trial to compare delivered Kt/V urea at dialysate flow rates of 600 and 800 ml/min in 42 patients. All other aspects of the dialysis prescription, including treatment time, blood flow rate, and dialyzer, were kept constant for a given patient. Delivered single-pool and equilibrated Kt/V urea were calculated from pre- and postdialysis plasma urea concentrations, and ionic Kt/V was determined from serial measurements of ionic dialysance made throughout each treatment. Results: Delivered Kt/V urea differed between centers; however, the difference in Kt/V urea between dialysate flow rates of 800 and 600 ml/min was NS by any measure (95% confidence intervals of-0.064 to 0.024 for single-pool Kt/V urea,-0.051 to 0.023 for equilibrated Kt/V urea, and-0.029 to 0.099 for ionic Kt/V). Conclusions: These data suggest that increasing the dialysate flow rate beyond 600 ml/min for these dialyzers offers no benefit in terms of delivered Kt/V urea. © 2011 by the American Society of Nephrology.