Transcatheter closure of large atrial septal defects in 18 patients

Abstract

Purpose: This study was designed to evaluate the efficacy and safety of transcatheter closure of large atrial septal defects (ASD). Methods: Eighteen patients diagnosed as ostium secundum defect with a diameter of 30-40 mm were enrolled in this study. With the guidance of echocardiography and fluoroscopy, the Amplazter occlusion devices were implanted percutaneously through the femoral vein. Results: A small residual left-to-right shunt was detected with echocardiography immediately postprocedure but resolved after 1 week. The occlusion devices remained in proper position, and there was no residual shunt at 1- and 29-month follow-ups. Cardiac function and atrial sizes improved significantly as compared with the preclosure states. Conclusions: Transcatheter closure of large atrial septal defects with the Amplazter occlusion device is feasible, safe and effective. © 2008 Wiley Periodicals, Inc.