Purpose. An objective, quantitative, and sensitive method to map retinal thickness is needed to diagnose more effectively the conditions causing alterations in thickness, such its macular edema and neuroretinal atrophy. Methods. An instrument, the retinal thickness analyzer, was developed into a rapid scanning instrument, capable of covering macular areas of 2 x 2 mm in 200 or 400 msec and generating a detailed map of the retinal thickness. The performance was assessed in vitro and in five normal subjects who were scanned on three separate visits. Results. Optimal depth precision was 5 to 10 μm, and the optimal depth resolution was 50 μm. Reproducibility was ±12 μm on the same day, ±13 μm for single maps obtained in multiple visits, and ±10 μm for three averaged maps per visit obtained in multiple visits. Conclusions. This new method to analyze retinal thickness provides four unique features: multiple optical cross-sectioning of the retina, mapping of retinal thickness, high reproducibility, and short acquisition time. These capabilities promise to improve the diagnosis and management of common diseases such as macular edema and glaucoma.
Zeimer, R., Shahidi, M., Mori, M., Zou, S., & Asrani, S. (1996). A new method for rapid mapping of the retinal thickness at the posterior pole. Investigative Ophthalmology and Visual Science, 37(10), 1994–2001. https://doi.org/10.1016/s0002-9394(14)70413-1