Association of the polymorphism exon 1 (A/o) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Abstract

Introduction: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions-550 (H/L variant, rs11003125) and-221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. Methods: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. Results: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. Conclusions: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.