Local oscillatory brain dynamics of mind wandering in schizophrenia

Abstract

A number of studies have focused on brain dynamics underlying mind wandering (MW) states in healthy people. However, there is limited understanding of how the oscillatory dynamics accompanying MW states and task-focused states are characterized in clinical populations. In this study, we explored EEG local synchrony of MW associated with schizophrenia, under the premise that changes in attention that arise during MW are associated with a different pattern of brain activity. To this end, we measured the power of EEG oscillations in different frequency bands, recorded while participants watched short video clips. In the group of participants diagnosed with schizophrenia, the power in MW states was significantly lower than during task-focused states, mainly in the frontal and posterior regions. However, in the group of healthy controls, the differences in power between the task-focused and MW states occurred exclusively in the posterior region. Furthermore, the power of the frequency bands during MW and during episodes of task-focused attention correlated with cognitive variables such as processing speed and working memory. These findings on dynamic changes of local synchronization in different frequency bands and areas of the cortex can improve our understanding of mental disorders, such as schizophrenia.