Delivering DNA origami to cells

41Citations
Citations of this article
152Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

DNA nanotechnology research has long-held promise as a means of developing functional molecules capable of delivery to cells. Recent advances in DNA origami have begun to realize this potential but is still at the earliest stage and a number of hurdles remain. This review focuses on progress in addressing these hurdles and considers some of the challenges still outstanding. These include stability of such structures necessary to reach target cells after administration; methods of cell targeting and uptake; strategies to avoid or escape endosomes and techniques for achieving specific subcellular localization. Finally, the functionality that can be expected once DNA origami structures reach their final intracellular targets will be considered.

Cite

CITATION STYLE

APA

Balakrishnan, D., Wilkens, G. D., & Heddle, J. G. (2019, April 1). Delivering DNA origami to cells. Nanomedicine. Future Medicine Ltd. https://doi.org/10.2217/nnm-2018-0440

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free