Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab

Abstract

Background: Although infliximab has high efficacy in treating TNFα-associated diseases, the epitope on TNFα remains unclear. Results: The crystal structure of the TNFα in complex with the infliximab Fab is reported at a resolution of 2.6 Å. Conclusion: TNFα E-F loop plays a crucial role in the interaction. Significance: The structure may lead to understanding the mechanism of mAb anti-TNFα. Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.