Abstract
(Chemical Presented) 120 years after the discovery of the Reformatsky reaction, the first effective catalytic enantioselective Reformatsky reaction with aldehydes using a binol derivative as a chiral catalyst is presented (see scheme; TMS = trimethylsilyl). The reaction is performed with ethyl iodoacetate and Me2Zn. The presence of air is found to be crucial to reach high conversions and selectivities. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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Fernández-Ibáñez, M. Á., Maciá, B., Minnaard, A. J., & Feringa, B. L. (2008). Catalytic enantioselective Reformatsky reaction with aldehydes. Angewandte Chemie - International Edition, 47(7), 1317–1319. https://doi.org/10.1002/anie.200704841
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