The MTOC/Golgi complex at the T-cell immunological synapse

4Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.
Get full text

Abstract

T cells effectively explore the tissue in search for antigens. When activated, they dedicate a big amount of energy and resources to arrange a complex structure called immunological synapse (IS), containing a particular distribution of molecules defined as supramolecular activation clusters (SMACs), and become polarized toward the target cell in a manner that channels the information specifically. This arrangement is symmetrical and requires the polarization of the MTOC and the Golgi to be operational, especially for the proper delivery of lytic granules and the recycling of molecules three dimensionally segregated at the clustered interface. Alternatively, after the productive encounter, T cells need to rearrange again to newly navigate through the tissue, changing back to a motile state called immunological kinapse (IK). In this IK state, the MTOC and the Golgi apparatus are repositioned and recruited at the back of the T cell to facilitate motility, while the established symmetry of the elements of the SMACs is broken and distributed in a different pattern. Both states, IS and IK, are interchangeable and are mainly orchestrated by the MTOC/Golgi complex, being critical for an effective immune response.

Cite

CITATION STYLE

APA

Roig-Martinez, M., Saavedra-Lopez, E., Casanova, P. V., Cribaro, G. P., & Barcia, C. (2019). The MTOC/Golgi complex at the T-cell immunological synapse. In Results and Problems in Cell Differentiation (Vol. 67, pp. 223–231). Springer Verlag. https://doi.org/10.1007/978-3-030-23173-6_9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free