Skip to main content

Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019

  • Wong M
  • Javornik Cregeen S
  • Ajami N
  • et al.
N/ACitations
Citations of this article
297Readers
Mendeley users who have this article in their library.
Get full text
This PDF is freely available from an open access repository. It may not have been peer-reviewed.

Abstract

A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.

Cite

CITATION STYLE

APA

Wong, M., Javornik Cregeen, S., Ajami, N., & Petrosino, J. (2020). Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019. BioRxiv : The Preprint Server for Biology. https://doi.org/10.1101/2020.02.07.939207

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free