Role of anti-β-glucan antibody in host defense against fungi

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We have recently detected an anti-β-glucan antibody in normal human and normal mouse sera. The anti-β-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-β-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-β-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall β-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-β-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-β-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi. © 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.




Ishibashi, K. I., Yoshida, M., Nakabayashi, I., Shinohara, H., Miura, N. N., Adachi, Y., & Ohno, N. (2005). Role of anti-β-glucan antibody in host defense against fungi. FEMS Immunology and Medical Microbiology, 44(1), 99–109.

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