Correlation of enhancement Mean Platelet Volume (MPV) with severity of dengue infection

Abstract

Dengue infection is one of the infectious diseases which become a health problem in the world. Platelets play an important role in the pathogenesis of dengue. The quantity of platelet related to dengue were often discussed but the quality of platelet related to dengue infection were rarely discussed. The activation of platelets can be observe indirectly through changes in MPV. Aim of this study is to analyze the prevalence ratio of MPV enhancement in dengue hemorrhagic fever (DHF) compared to dengue fever (DF). This study is an observational analytical study with a cross-sectional design to analyze the prevalence ratio of enhancement MPV in DHF compared to DF. The subjects were dengue suspected patients that hospitalized in Dr. Sardjito General Hospital and PKU Muhammadiyah Hospital Yogyakarta who meet the inclusion and exclusion criteria. Venous blood were collected into 2 mL EDTA tube for automatical hematology analysis. Chi-square was used to analyze different proportions of MPV enhancement between DHF and DF groups. One hundred subjects were participated in this study and classified into DF and DHF based on WHO 2011 criteria. Prevalence ratio of MPV enhancement ≥ 9.7 fL was 4.8 (95% CI 2.8-37.0), p < 0.0001. The result indicates that MPV enhancement was a risk factor of worsening dengue infection.