Rescue High-Frequency Oscillatory Ventilation for Congenital Diaphragmatic Hernia: What about Lung Histopathology and Necropsy Findings?

Abstract

Introduction . It is not yet a resolved issue whether HFOV (high-frequency oscillatory ventilation), used as primary mode or as rescue ventilation, has benefit over conventional mechanical ventilation for CDH (congenital diaphragmatic hernia) patients treatment. Purpose . To evaluate the success rate of rescue HFOV for CDH, and the histological characteristics of the lungs, at the autopsy of the deceased patients. Material and Methods . Out of 80 CDH patients, 10 were treated with rescue HFOV. The success of HFOV, histological exam of the lungs of deceased patients, and data on the followup of discharged patients were assessed. Results . Rescue HFOV was started between two hours and four days of life. The success rate of rescue HFOV was 20% (2/10). Autopsy findings along with pulmonary hypoplasia included coarctation of aorta ( n = 1 ) , pneumonia ( n = 3 ) , meconium aspiration ( n = 2 ) , hyaline membranes ( n = 2 ) , severe muscular hypertrophy of medium and small diameter lung arteries ( n = 1 ) , severe lung hypoplasia ( n = 1 ) , pleural effusions ( n = 2 ) , haemorrhagic diatesis ( n = 2 ) , and signs of overwhelming sepsis ( n = 1 ) . The five-years follow up of the two survivors revealed normal growth and neurodevelopment. Conclusions . The results of this study support the idea that rescue HFOV may increase survival of CDH patients, when conventional mechanical ventilation fails.