The antibacterial surface based on polymer brush

Abstract

The application of biomedical materials suffers from bacterial infection because of the adherent bacteria would form a biofilm on the surface of the material and cause a pathogenic infection, it creates huge challenges especially in healthcare, such as surgical equipment in hospitals and medical implants.In order to prevent the adhesion of nonspecificbacteria,the polymer brush has beenscouted and become a reliable way which has controllable brush thickness, strong mechanical stability andfurther modification potential. In this paper,we summarized the recent progress of antibacterial surface based on polymer brush. he preparation method of surface polymeric brush including the"graftmgto "and"graftmgfrom"method is expounded in detail.According to the mechanism of bacterial infection, there are three strategies to settle this problem.The first one is regulating the adhesion behavior of bacteria on the surface of materials to block the first step of infection. Then sterilization strategy using bactericide to kill bacteria adhering to the surface of the material directly. And the anti-adhesion bactericidal combination strategy has the advantage of sterilizing for a long time which can make up the shortcomings of the above two methods.However, it is still in the early stages of fully solving the problem,the long-lasting, efficient,and environmentally friendly antibacterial composite surfaces is in urgent need.