The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2)

Abstract

Background: miR-663 is related to chemosensitivity in human breast cancer cells. Results: Overexpression of miR-663 was associated with chemoresistance and accompanied by down-regulation of HSPG2. Conclusion: Overexpression of hypomethylated miR-663 induces chemoresistance in breast cancer cells by down-regulating HSPG2. Significance: Learning how miR-663 regulates chemoresistance may provide a potential target for the miRNA-based approach of breast cancer therapy. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.