Alterations in trabecular bone μ-architecture and cartilages in rats with antigen-induced arthritis (AIA) resulting from synchrotron-based X-ray imaging analysis

Abstract

It is widely demonstrated that phase contrast imaging yields better contrast resolution on soft-tissue with respect to conventional absorption radiography. In this feasibility study an application of synchrotron radiation imaging for arthritic bone erosion is presented. In particular two phase-contrast imaging techniques are investigated and analyzed in order to differentiate different aspects of bone microarchitecture and cartilages, with the ultimate aim to demonstrate the translation of the technique in in-vivo studies.