Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

Abstract

Objective: To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index. Design: Cross-sectional study. Setting: Tertiary teaching hospital. Patient(s): Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m2). Intervention(s): Clinical evaluation and venipuncture. Main Outcome Measure(s): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test. Result(s): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups. Conclusion(s): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability. © 2013 by American Society for Reproductive Medicine.