Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells

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Abstract

The stimulation of NMDA receptor increased [3H]GABA release from preloaded cultured retina cells. This effect appears to he mediated by KO production, since addition of L-NA reduces NMDA-evoked [3H]GABA release. Spermine/ NO complex, an NO donor, mimics the effect produced by NMDA. The addition of zaprinast, a phosphodiesterase inhibitor, as well as 8-Br-cGMP enhances the NMDA-evoked [3H]-GABA release. These results agree with the existence in chick retina cells of NO/cGMP pathways and support a role for NO in NMDA-evoked events. The activation of this receptor complex through maturative stages of the retina together with the SO-mediated increase in GABA release may account for NMDA differentiative effect in culturing retina cells.

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Ientile, R., Pedale, S., Picciurro, V., MacAione, V., Fabiano, C., & MacAione, S. (1997). Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells. FEBS Letters, 417(3), 345–348. https://doi.org/10.1016/S0014-5793(97)01322-7

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