Genomic analysis: Toward a new approach in breast cancer management

18Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

Breast cancer is a clinically heterogeneous and complex disease that can affect differently individuals with seemingly identical clinicopathologic parameters. This heterogeneity is strictly linked to individuals and tumors genetic variability. Currently, the development of high-throughput technologies are proving novel tools to tackle this complexity. By DNA microarray technology, genomic analysis has been used successfully for breast carcinomas stratification into molecular subgroups with relevant implications for clinical outcomes, and detection of prognostic/treatment predictive signatures. Indeed, DNA microarray has rapidly improved becoming a powerful diagnostic tool. Information derived from these assays allows clinicians to estimate the risk for distant recurrence, and predict accurately which patients are likely to benefit from adjuvant therapy. This review will describe the state-of-the-art of genomic analysis in breast cancer and introduce the clinicians to a genomic approach to cancer management, illustrating how it can help in defying a better diagnosis, prognosis and therapeutic treatment. © 2011 Elsevier Ireland Ltd.

Cite

CITATION STYLE

APA

Cavallaro, S., Paratore, S., de Snoo, F., Salomone, E., Villari, L., Buscarino, C., … Basile, F. (2012, March). Genomic analysis: Toward a new approach in breast cancer management. Critical Reviews in Oncology/Hematology. https://doi.org/10.1016/j.critrevonc.2011.03.006

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free