Cerebrovascular reactivity is a main determinant of white matter hyperintensity progression in CADASIL

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Abstract

BACKGROUND AND PURPOSE: Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease. The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL. MATERIALS AND METHODS: Basal TCBF was measured in 25 NOTCH3 mutation carriers and 13 control subjects at baseline. CVR after administration of acetazolamide was measured in 14 NOTCH3 mutation carriers and 9 control subjects. Increase in white matter hyperintensities (WMHs), lacunar infarcts, and microbleeds on MR imaging was measured 7 years later. RESULTS: Lower CVR at baseline was associated with larger increase of WMHs (P = .001) but not with a larger increase of lacunar infarcts or microbleeds. TCBF at baseline was not associated with an increase of MR imaging abnormalities. CONCLUSIONS: Decreased CVR is a potential predictor of disease progression as indicated by increasing WMHs in CADASIL.

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Liem, M. K., Lesnik Oberstein, S. A. J., Haan, J., Boom, R. V. D., Ferrari, M. D., Buchem, M. A. V., & Grond, J. V. D. (2009). Cerebrovascular reactivity is a main determinant of white matter hyperintensity progression in CADASIL. American Journal of Neuroradiology, 30(6), 1244–1247. https://doi.org/10.3174/ajnr.A1533

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