Prostacyclin enhances mouse embryo development and hatching but not increased embryonic cell number and volume

9Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Objective: To evaluate in vitro effects of prostacyclin (PGI2), we cultured mouse embryos with a PGI2 analogue, because human fallopian tube cells synthesize abundant amounts of PGI2. Design: Animal model. Setting: Animal study in a private infertility clinic. Animal(s): Mouse embryos. Intervention(s): In vitro effects of PGI2 analogue on mouse embryos. Main Outcome Measure(s): Development rate, blastocyst volume, rate of complete hatching, and cell number of hatched blastocysts. Result(s): Exposure to PGI2 analogue during the four-cell to morula stages was critical to enhanced embryo development and hatching but did not increase blastocyst volume or cell number of hatched blastocysts. The effects of PGI2 analogue were statistically significant at 1.0 μmol/L and 2.0 μmol/L in human tubal fluid medium, with or without 1% bovine serum albumin. Conclusion(s): Prostacyclin analogue enhanced embryo development and hatching, but PGI2 did not increase number of cells in hatched blastocysts or blastocyst volume. © 2006 American Society for Reproductive Medicine.

Author supplied keywords

Cite

CITATION STYLE

APA

Liu, C. H., Lee, M. S., Hsieh, C. H., Huang, C. C., Tsao, H. M., & Hsieh, Y. S. (2006). Prostacyclin enhances mouse embryo development and hatching but not increased embryonic cell number and volume. Fertility and Sterility, 86(4 SUPPL.), 1047–1052. https://doi.org/10.1016/j.fertnstert.2006.05.002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free