The significance of a common idiotype (1F7) on antibodies against human immune deficiency virus type 1 and hepatitis C virus

0Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.

Author supplied keywords

Cite

CITATION STYLE

APA

Muller, S., Parsons, M. S., Kohler, H., & Grant, M. (2016). The significance of a common idiotype (1F7) on antibodies against human immune deficiency virus type 1 and hepatitis C virus. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2016.00011

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free