In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.
Muller, S., Parsons, M. S., Kohler, H., & Grant, M. (2016). The significance of a common idiotype (1F7) on antibodies against human immune deficiency virus type 1 and hepatitis C virus. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2016.00011