In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2α phosphorylation improves glucose tolerance and β cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins. © 2009 Elsevier Inc. All rights reserved.
Wek, R. C., & Anthony, T. G. (2009, July 8). Beta Testing the Antioxidant Function of eIF2α Phosphorylation in Diabetes Prevention. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.06.005