Beta Testing the Antioxidant Function of eIF2α Phosphorylation in Diabetes Prevention

Abstract

In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2α phosphorylation improves glucose tolerance and β cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins. © 2009 Elsevier Inc. All rights reserved.