Single-nucleotide polymorphism in the fadD28 gene as a genetic marker for east asia lineage Mycobacterium tuberculosis

Abstract

Mycobacterium tuberculosis isolates with a region of difference 105 (RD105) deletion, mainly Beijing family spoligotypes, were phylogenetically grouped into the East Asia lineage. We identified a single nucleotide polymorphism in codon 507, ATC to ATT, of the fadD28 gene as a robust marker and developed a rapid assay for East Asia lineage M. tuberculosis. Copyright © 2010, American Society for Microbiology. All Rights Reserved.