Child neurology: Differential diagnosis of a low CSF glucose in children and young adults

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Abstract

Analysis of CSF is daily routine in patients with acute neurologic disorders like CNS infections. In those patients, the finding of a low CSF glucose may influence further diagnostic workup and therapeutic choices. The interpretation of a low CSF glucose in patients with a chronic neurologic disorder, however, is a less common practice. We present a practical overview on the differential diagnosis of a low CSF glucose and stress the importance of recognizing a low CSF glucose as the diagnostic marker for GLUT1 deficiency syndrome, a treatable neurometabolic disorder. © 2013 American Academy of Neurology.

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Leen, W. G., De Wit, C. J., Wevers, R. A., Van Engelen, B. G., Kamsteeg, E. J., Klepper, J., … Willemsen, M. A. (2013). Child neurology: Differential diagnosis of a low CSF glucose in children and young adults. Neurology, 81(24). https://doi.org/10.1212/01.wnl.0000437294.20817.99

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