Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions. © 2006 Elsevier Inc. All rights reserved.
Berriel Diaz, M., Lemke, U., & Herzig, S. (2006, November). Discovering orphans’ sweet secret: NR4A receptors and hepatic glucose production. Cell Metabolism. https://doi.org/10.1016/j.cmet.2006.10.005