Aristolactams and Flavanones from Dasymaschalon wallichii (Hook.f. & Thomson) Jing Wang & R.M.K.Saunders and Their α-Glucosidase Inhibitory Activity

Abstract

The first phytochemical investigation of the twig and leaf extracts of Dasymaschalon wallichii led to the isolation and identification of 10 compounds, including 6 airstolactam alkaloids (1-6), 3 flavonoids (7-9) and one chalcone (10). The structures were elucidated through the analysis of NMR spectroscopic data and comparisons with those reported in the literature. Compounds 1-4 and 7-10 were evaluated for their α-glucosidase inhibitory activity. Among them, aristolactam AII (1) and 8-formyl-5,7dihydroxyflavanone (8) showed α-glucosidase inhibitory activity with IC50 values of 62.9 and 83.9 μM, respectively, which are better than the positive control (acarbose, IC50 = 178.2 μM). The potential binding modes of active compounds with α-glucosidase were also analyzed by molecular docking.