Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei

R. S.N. Brilhante; L. G.A. Valente; M. F.G. Rocha; T. J.P.G. Bandeira; R. A. Cordeiro; R. A.C. Lima; J. J.G. Leite; J. F. Ribeiro; J. F. Pereira; D. S.C.M. Castelo-Branco; A. J. Monteiro; J. J.C. Sidrim

Journal ArticleOPEN ACCESS

Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei

Antimicrobial Agents and Chemotherapy (2012) 56(4) 2198-2200

DOI: 10.1128/AAC.05885-11

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Abstract

This study aimed to evaluate the in vitro combination of farnesol and β-lactams against Burkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P≤0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains of B. pseudomallei. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Brilhante, R. S. N., Valente, L. G. A., Rocha, M. F. G., Bandeira, T. J. P. G., Cordeiro, R. A., Lima, R. A. C., … Sidrim, J. J. C. (2012). Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, 56(4), 2198–2200. https://doi.org/10.1128/AAC.05885-11

Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei

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