Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription

278Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

We have discovered a protein termed Dr1 that interacts with the TATA-binding protein, TBP. The association of Dr1 with TBP results in repression of both basal and activated levels of transcription. The interaction of Dr1 with TBP precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Dr1 activity is associated with a 19 kd protein. A cDNA clone encoding Dr1 was isolated. Dr1 is phosphorylated in vivo and phosphorylation of Dr1 affected its interaction with TBP. Our results suggest a regulatory role for Dr1 in repression of transcription mediated via phosphorylation. © 1992.

Cite

CITATION STYLE

APA

Inostroza, A., Mermelstein, F. H., Ha, I., Lane, W. S., & Reinberg, D. (1992). Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell, 70(3), 477–489. https://doi.org/10.1016/0092-8674(92)90172-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free