Gastroprotective Effect of Propolis Against Male White Mice Gastric Ulcers Induced by Aspirin

Abstract

A peptic ulcer is an inflammation of the stomach wall that can cause wounds in the gastric mucosa. Consumption of aspirin over therapeutic doses can cause injury to the stomach. Propolis is known to have an effect to protect stomach damage. This study aims to find out the effect of propolis on male white mice-induced peptic ulcers. A total of 20 mice were divided into 4 experimental groups. The first group was negative control, the second group was positive control (aspirin 350 mg/kg bodyweight for 5 days), the third group was given propolis 500 mg/kg bodyweight for 7 days, and the last group was given propolis then induced with aspirin. The preparations were administered orally. After the treatment, mice were sacrificed to obtain gastric tissue. The tissue was observed macroscopically and microscopically. The data were analyzed descriptively using the average of gastric ulcer index and histopathological analysis. Based on the results of the study, the administration of propolis followed by aspirin has a gastroprotective effect with an average ulcer index of 1, compared to the aspirin group with an ulcer index of 2.5. It can be concluded that the administration of propolis at a dose of 500 mg/kg body weight has a protective effect against male white mice gastric ulcers induced by aspirin.