Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

Abstract

We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid. The dehydration of cocrystals of macro-dimensions results in destruction of crystal morphology; however, crystal morphology is retained when the cocrystal is reduced to nanometer-dimensions, despite a lack of pores to accommodate loss of water.