Meta-analysis of the effectiveness of combined enteral nutrition therapy for inflammatory bowel disease

Abstract

Background: So far, there are still many difficulties in the treatment of inflammatory bowel disease (IBD), among which enteral nutrition (EN) is the most valuable and controversial treatment. Therefore, this study will compare the effectiveness of conventional medication with EN in the treatment of inflammatory bowel disease. Methods: Searching the Pubmed, Embase, Web of Science, Cochrane Library, Clinical trial, CNKI, Chinese biomedical literature, VIP, and Wanfang databases, Randomized controlled trials and cohort studies on conventional drug+EN and conventional drug therapy for IBD were also retrieved, The data of their efficiency and nutritional status (hemoglobin, albumin, and body mass index) were extracted independently, After a qualitative evaluation of the included literature. The meta-analysis was performed using the RevMan5.3 software. Results: A total of 33 study articles were included, including 2466 IBD patients, 1248 patients in the test group (conventional drugs combined with EN), and 1218 patients in the control group (conventional drugs). The meta-analysis showed that the clinical response of conventional drugs with EN for IBD was higher than the conventional drug group (RR=1.25, 95% CI: 1.17-1.34, Z=6.37, P