Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to promote TIC expansion.
Qu, L., Wu, Z., Li, Y., Xu, Z., Liu, B., Liu, F., … Wang, L. (2016). A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Nature Communications, 7. https://doi.org/10.1038/ncomms12692