Formulation and development of dental gel containing clove oil for the treatment of human periodontal diseases

Abstract

Aim: The study was aimed to develop and evaluate dental gel containing clove oil as the chief constituent for the treatment of periodontitis. Methods: It has a wide spectrum of antibacterial activity against a number of periodontal pathogens, hence it is selected for the treatment of periodontitis. Clove oil gel is formulated by using carbopol 934 as gelling agent, clove oil as medicinal agent, polyethylene glycol co-solvent, methyl paraben and propyl paraben as preservative and required quantity of distilled water as vehicle. Results: The clove oil was evaluated for physical parameters like acid value, ester value, specific gravity and refractive index and it shown satisfactory results. The prepared gel was evaluated for various properties such as antimicrobial activity, pH, spreadability, extrudability, drug content etc. In-Vitro experiments demonstrated that the formulation F3 is a suitable dosage form for the treatment of periodontitis. Clove oil showed the zone of inhibition of about 22.05±0.04 mm. Conclusion: On the basis of the result obtained in this present study we conclude that the gel formulations of clove oil F3 showed good physicochemical properties as well as good drug content compared to other formulations.