Chemical constituents and anti-ulcer activity of ethylacetate extract of the leaves of Sanchezia nobilis Hook.F.

Abstract

Study have two objectives. First objective is about the identification of the five components. The second objective is about the antiulcer activity of the ethylacetate extract. Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis Hook.F. collected in Nam Dinh province by chromatographic methods. These compounds were identified as: Quercetin (1), Scopoletin (2), Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3), Quercetin-3-O-α-L-rhamnosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside (4),3'-Omethyl- 3,4-methylenedioxy ellagic acid (5).Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compounds 3, 4, 5 were isolated from the leaves of Sanchezia nobilis Hook.F. for the first time. Evaluation the effect of gastric and duodenal anti-ulcer on cyteamine induced gastric ulcer models indicates at this ethylacetate extract has the effect to improve the extent of ulcer lesions treatment (54,17 %); obviously reduced the average of number pocket of ulcers (1,85 ± 0,80) and ulcer index (5,61 ± 2,69), however, it does not change the area of the ulcer.