Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin1

Abstract

Although considerable strides have been made in charting the physiology and pathophysiology of inhibin in the human, further progress awaits the development of recombinant inhibin suitable for administration in human studies. Measurements of total serum inhibin, although inadequate to chart the dynamic changes associated with normal and disordered pituitary-gonadal function, have proven to be of value as indices of ovarian tumor activity. Although the roles of specific dimeric inhibin measurements in clinical practice have not been clearly established, advances in our understanding of inhibin physiology and pathophysiology in the human suggest that inhibin B may have value as a marker of Sertoli cell function in men with infertility and as a prognostic indicator in women undergoing ovulation induction therapy.